UCL Institute of Neurology, University College London, London, UK

Giampietro Schiavo

Biosketch

Giampietro (Gipi) Schiavo heads the Molecular Neuropathobiology laboratory (http://www.ucl.ac.uk/ion/departments/sobell/Research/GSchiavo) in the Department of Neuromuscular Disease, Institute of Neurology, University College London (UCL). He is the academic lead of the ARUK UCL Drug Discovery Institute and is a UK Dementia Research Institute Professor. Giampietro has a long-term interest in the mechanisms of action of bacterial protein toxins, in particular tetanus and botulinum neurotoxins, and their exploitation as tools in cell biology. Using these probes, his group has clarified key steps in the mechanism of ligand entry at the neuromuscular junction1 and the recruitment of ligand-receptor complexes to signaling endosomes moving along the axonal retrograde transport route2,3,4. This essential transport pathway, which allows the delivery of a variety of organelles and molecular complexes, is impaired in several nervous system pathologies2,5, such as motor neuron disease.

Selected publications:

  1. Deinhardt K, et al. (2006) Neuron 52:293-305.
  2. Bilsland L, et al. (2010) Proc Natl Acad Sci USA 107:20523–20528.
  3. Terenzio M, et al. (2014) EMBO J 33:1582-1598.
  4. Bercsenyi K, et al. (2014) Science 346:1118-1123
  5. Sleigh JN, et al. (2017) Proc Natl Acad Sci USA 114:E3324-E3333