I.R.C.C.S. Besta – Neurology Unit

University of Milan – Neuroscience Section, Department of Pathophysiology and Transplantation

Giacomo Comi


My research and clinical activities are dedicated to the study and treatment of patients with neurodegenerative and neuromuscular disorders, in particular mitochondrial and motor neuron diseases and muscular dystrophies. My major research focus has been on the identification of molecular mechanisms as well as on developing novel treatments of these disorders. In this regard, I contributed to the identification of causative genes of encephalomyopathies, limb girdle muscular dystrophies and familial ALS forms. Indeed, I have performed many pre-clinical studies to develop potential molecular and cellular treatment strategies for these conditions. Further, I have conducted several human clinical trials (in particular in Spinal Muscular Atrophy and Duchenne Muscular Dystrophy patients) to evaluate the safety and effectiveness of therapies in national and international trials. I am in charge of the activity of biochemical and genetic diagnostics at the Laboratory of Biochemistry and Genetics, University of Milan. I am the Director of Neuropediatric Unit and the Supervisor of neuromuscular and motor neuron our patient service at the IRCCS Foundation Ca’ Granda Hospital. I teach in many courses of the University of Milan at MD and PhD students, neurology residents and mentor several research fellows. I currently have one Research grant from the Ministry of Health, and several others research grants to conduct basic and clinical research in ALS, gene and stem cell therapy program for neuromuscular diseases. Taken together, my research efforts constitute a comprehensive program to translate basic science breakthroughs into effective treatments for patients with neurodegenerative and neuromuscular disease. I’m also serving as vice-director of Dino Ferrari Center for the Neuromuscular and Neurodegenerative disorders. In February 2014 I received the habilitation to Full Professor in Neurology.